Program - Helicase meeting

Sunday, July 31, 2011
4:00PM – 9:00AM	Conference Registration
6:00PM – 7:00 PM	FASEB Opening Reception
7:00PM – 8:30 PM	Dinner
8:45PM – 10:00PM	Keynote: Steven Kowalczykowski, UC Davis Watching Individual DNA Helicases and Motor Proteins Behaving and Misbehaving

Monday, August 1, 2011
7:30AM – 9:00AM	Breakfast
Session 1: 9:00AM – 12:15PM	Physical Mechanisms of Helicases and Translocases I Chair: Timothy Lohman, Washington University
9:00AM – 9:15AM	Welcome from FASEB
9:15AM - 9:45AM	Karl-Peter Hopfner, University of Munich Structure and Mechanism of the Swi2/Snf2 Remodeler Mot1 in Complex with Its Substrate TBP
9:45AM –10:15AM	Dale Wigley, Institute of Cancer Research, London, U.K. Structure and Mechanism of AddAB
10:15AM – 10:30 AM	Davis Jose, University of Oregon Helicase Movement in the Replication Fork is Controlled by Position-Specific DNA Base-pair ‘Breathing’
10:30AM – 11:00AM	Group photo & FASEB Sponsored Coffee Break
11:00AM – 11:30AM	Taekjip Ha, University of Illinois/HHMI Reeling in DNA One Nucleotide at a Time: Repetitive Looping Coupled with PcrA Translocation
11:30AM – 12:00PM	Timothy Lohman, Washington University Coupling of the RecB and RecD Motors During Translocation by RecBCD
12:00PM – 12:15PM	Ilya Finkelstein, Columbia University Single-molecule Imaging Reveals Mechanisms of How RecBCD Helicase Strips DNA-bound Obstacles
12:15PM – 1:15PM	Lunch
	Free Afternoon
4:00PM – 6:00PM	Poster Session 1
6:00PM – 7:00PM	Dinner
Session 2: 7:00PM – 9:45PM	Physical Mechanisms of Helicases and Translocases II Chair: Smita Patel, UMDNJ
7:00PM - 7:30PM	Rick Russell, University of Texas Mechanisms of RNA Chaperone Activity by DEAD-box Proteins
7:30PM – 8:00PM	Maria Spies, University of Illinois/HHMI Single-molecule Studies of Human Recombinational Helicase FBH1
8:00PM – 8:15PM	Daniela Goldfarb, Weizman Institute Probing Conformational Variations at the ATPase Site of the RNA Helicase DbpA Upon Binding to Nucleotides and RNA by High Field ENDOR Spectroscopy
8:15PM – 8:30PM	Break
8:30PM – 8:45PM	Dagmar Klostermeier, University of Muenster Harnessing a Helicase Module: Nucleotide-driven Conformational Changes in the Helicase Domain Couple the Nucleotide Cycle to Positive DNA Supercoiling by Reverse Gyrase
8:45PM – 9:15PM	James Berger, University of California, Berkeley The Structural Basis for MCM2-7 Helicase Activation by GINS and Cdc45
9:15PM – 9:45PM	Smita Patel, Rutgers University Nucleotide Preference and Energy Coupling with Unwinding by the Hexameric T7 Helicase

Tuesday, August 2, 2011
7:30AM – 9:00AM	Breakfast
Session 3: 9:00AM – 12:00PM	Chromatin Structure and Remodeling Chair: Tom Owen-Hughes, University of Dundee
9:00AM - 9:30AM	Karolin Luger, Colorado State University/HHMI No ATP Required: The Altered States of the Nucleosome
9:30PM –10:00AM	Geeta Narlikar, University of California, San Francisco Understanding the Roles of the H4 Tail and Flanking DNA in Nucleosome Remodeling by ACF
10:00AM – 10:15AM	Blaine Bartholomew, Southern Illinois University Role of Domains Other than the ATPase Domain in Chromatin Remodeling
10:15AM – 10:45AM	FASEB Sponsored Coffee Break
10:45AM – 11:15PM	Tom Owen-Hughes, University of Dundee Structural and Functional Studies of Chromatic Organizing Enzymes
11:15PM – 12:00PM	Craig Peterson, University of Massachusetts, Worcester Chromatin Regulation of Genome Integrity
12:15PM – 1:15PM	Lunch
	Free Afternoon
4:00PM – 6:00PM	Poster Session 2
6:00PM – 7:00PM	Dinner
Session 4: 7:00PM – 10:00PM	Helicases in Post-Transcriptional Regulation of Gene Expression Chair: Beate Schwer, Weill Cornell Medical College
7:00PM - 7:30PM	Karsten Weis, University of California, Berkeley Conserved Mechanism of Activation of the DEAD-box ATPase Dbp5
7:30PM – 8:00PM	Beate Schwer, Weill Cornell Medical College RNA- and Protein-Interactions That Direct Pre-mRNA Splicing
8:00PM – 8:15PM	Ulf-Peter Guenther, Case Western Reserve University The DEAD-box RNA Helicase Ded1p Targets Long-Range RNA-RNA Interactions in mRNAs
8:15PM – 8:30PM	Break
8:30PM – 9:00PM	Katrin Karbstein, University of Michigan The Role of the Rok1-Rrp5 Complex in 40S Ribosome Assembly
9:00PM – 9:30PM	Alan Lambowitz, University of Texas Mss116p and CYT-19: DEAD-box Proteins that Function as General RNA Chaperones
9:30PM – 10:00PM	Rui Zhao, University of Colorado, Denver Structure, Mechanism, and Regulation of Spliceosomal Helicase Brr2

Wednesday, August 3, 2011
7:30AM – 9:00AM	Breakfast
Session 5: 9:00AM – 12:15PM	Helicases in Multi-Component Assemblies I Mark Szczelkun, University of Bristol
9:00AM - 9:30AM	Mark Szczelkun, University of Bristol Translocases and Switches: Roles for Helicase Domains in Long-range Communication on DNA
9:30PM –10:00AM	Steve West, London Research Institute Regulatory Control of the Holliday Junction Resolvases in Meiotic and Mitotic Cells
10:00AM – 10:15AM	Alessandro Vindigni, St. Louis University Understanding the Multiple Roles of RecQ Helicases in DNA Replication
10:15AM – 10:45AM	FASEB Sponsored Coffee Break
10:45AM – 11:15PM	Wolf-Dietrich Heyer, University of California, Davis Regulation of homologous Recombination: Functions of the Anti-recombinogenic Helicase Srs2 and the Rad51 Paralogs Rad55-Rad57
11:15PM – 11:45PM	Marc Boudvillain, CNRS Orleans A Ring-shaped RNA Chaperone that Binds and Inhibits a Ring-shaped Helicase: Regulation of Transcription Termination Factor Rho by the Sm-like Hfq Protein
11:45PM – 12:15PM	Herve LeHir, Université Pierre et Marie Curie-Paris RNA Helicases Involved in Nonsense-mediated mRNA Decay
12:15PM – 1:15PM	Lunch
	Free Afternoon
4:00PM – 6:00PM	Meet the Experts Session
6:00PM – 7:00PM	Dinner
Session 6: 7:00PM – 9:45PM	Helicases in Cancer and Aging Chair: Patricia Opresko, University of Pittsburg
7:00PM - 7:30PM	Robert Brosh, National Institutes of Health Mechanisms of FancJ DNA Helicase
7:30PM – 8:00PM	Patricia Opresko, University of Pittsburg Roles of the Werner Helicase in Human Genome Stability
8:00PM – 8:15PM	Kelly Hoadley, University of Wisconsin Biochemical and Structural Studies at the Interface Between the RMI Core Complex and FancM
8:15PM – 8:30PM	Break
8:30PM – 8:45PM	Dorina Saro, Yale University Structural Insights into the Function of FancM-mediated Complexes
8:45PM – 9:15PM	Ken Marians, Sloan-Kettering Mechanisms of Replication Restart
9:15PM – 9:45PM	Ian Hickson, University of Copenhagen Role of RecQ Helicase Complexes as DNA Structure-Specific ‘Dissolvasomes’

Thursday, Aug. 4, 2011
7:30AM – 9:00AM	Breakfast
Session 7: 9:00AM – 11:45PM	Helicases and Translocases in Viral Replication Chair: Anna Marie Pyle, Yale University
9:00AM - 9:30AM	Stephen Cusack, EMBO Grenoble Structural and Functional Studies of RIG-I like Helicases (RLHs) – Innate Immune Receptors that Recognize Viral RNA
9:30PM –10:00AM	Ellen Fanning, Vanderbilt University Role of Human DNA Helicase B in Replication Fork Surveillance and Recovery
10:00AM – 10:15AM	Stephen White, St. Jude Children’s Research Hospital The Structure and Mechanism of the T4 Phage SF1B Helicase Dda
10:15AM – 10:45AM	FASEB Sponsored Coffee Break
10:45AM – 11:15PM	Xiaojiang Chen, University of Southern California Structural Mechanisms of MCM and SV40 T-antigen Helicases
11:15PM – 11:45PM	Anna Marie Pyle, Yale University/HHMI RNA recognition and mechanical function of RIG-I: a molecular machine for mediating innate immunity
11:45PM – 12:15PM	Business Meeting
12:15PM – 1:45PM	Lunch
1:00PM – 6:00PM	Free Afternoon
6:00PM – 7:00PM	Dinner
Session 8: 7:00PM – 9:45PM	Helicases and Translocases in Genome Maintenance and Replication Chair: Virginia Zakian, Princeton University
7:00PM - 7:30PM	Opher Gileadi, Oxford University Structural Mechanisms of Human RecQ DNA Helicases
7:30PM – 8:00PM	Mark Dillingham, University of Bristol Recombination Hotspots and Single-Stranded DNA Binding Proteins Couple DNA Translocation to DNA Unwinding by the AddAB Helicase-Nuclease
8:00PM – 8:15PM	Michael Trakselis, University of Pittsburg Wrapping of ssDNA Around the Exterior Surface of Hexameric Helicases During Unwinding
8:15PM – 8:30PM	Break
8:30PM – 8:45PM	Aklank Jain, University of Texas Dhx9 Helicase is Involved in Maintaining Genomic Stability in Human Cells
8:45PM – 9:15PM	Viginia Zakian, Princeton University Common and Uncommon Functions of Pif1 Family DNA Helicases
9:15PM – 9:45PM	Peter McGlynn, University of Aberdeen Properties of Helicases Required for Underpinning Replication of Protein-bound DNA

Friday, August 5, 2011
7:30AM – 8:30AM	Breakfast
Session 9: 8:30AM – 11:30PM	Helicases in Multi-Component Assemblies II Chair: Kevin Raney, University of Arkansas
8:30AM - 9:00AM	Kevin Raney, University of Arkansas Physical and Functional Interaction Between Yeast Pif1 Helicase and Rim1 Single-stranded DNA Binding Protein
9:00AM – 9:30AM	Felix Halbach, Max Planck Institute, Munich Structure and Mechanisms of the Ski2-Ski3-Ski8 Complex, the Regulator of the Cytoplasmic RNA Exosome
9:30AM – 9:45AM	Guramrit Singh, University of Massachusetts Transcriptome-Wide Mapping of Exon Junction Complex Occupancy Reveals Higher Order mRNP Structure
9:45AM – 10:00AM	Break
10:00AM – 10:15AM	Jean-Phillip Didier, University of Geneva A DEAD-box RNA Helicase Plays a Major Role in Staphylococcus aureus Virulence Expression
10:15AM – 10:45AM	Frances Fuller-Pace, University of Dundee A Novel miRNA Encoded within a Conserved Intron in the p68 (DDX5) RNA Helicase Gene: Association with Poor Survival in Brest Cancer
10:45AM – 11:15PM	Roman Tuma, University of Leeds Mechanism of RNA Packaging Motor
11:15AM – 11:30AM	Closing Comments
11:30AM	Departures Boxed Lunches Available